Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles
نویسندگان
چکیده
منابع مشابه
Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles
Pyrazolidinones were prepared in a two-step sequence starting from α-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade.
متن کاملCopper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles.
A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents.
متن کاملCopper-Triggered Aggregation of Ubiquitin
Neurodegenerative disorders share common features comprising aggregation of misfolded proteins, failure of the ubiquitin-proteasome system, and increased levels of metal ions in the brain. Protein aggregates within affected cells often contain ubiquitin, however no report has focused on the aggregation propensity of this protein. Recently it was shown that copper, differently from zinc, nickel,...
متن کاملCopper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides.
A copper-catalyzed coupling of α-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of α-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and (13)C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxy...
متن کاملA straightforward approach towards thiazoles and endothiopeptides via Ugi reaction.
Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2011
ISSN: 1860-5397
DOI: 10.3762/bjoc.7.153